Interactive Quiz: Joint Pain

Answer: Surgical excision of skin lesions 

The patient was discharged home with oral morphine as needed for pain, physical therapy, and outpatient follow-up with medical genetics, palliative care, and dermatology specialists.

In some cases, surgical excision of skin lesions can be considered, although recurrence can occur, and partial or radical gingivectomy may be helpful for gingival hyperplasia.

ISH is a progressive disease that typically results in death by aged 2 years, most often secondary to intractable diarrhea, recurrent infections, and organ failure. Cases of longer survival have been reported.

To read the full case report, see:

Goldstein J, Meepos L, Zipkin R. Infantile systemic hyalinosis. Consultant. 2019;59(3):90-92. https://www.consultant360.com/article/rheumatology/infantile-systemic-hyalinosis?page=0.