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An Infant’s Sudden-Onset Rash and Swelling: Can You Identify the Cause?

Volume 58 - Issue 6 - June 2018

  • Answer: Acute Hemorrhagic Edema of Infancy

    A hematologist was consulted, who made the diagnosis of acute hemorrhagic edema of infancy (AHEI).

    AHEI is an immune complex–mediated small-vessel leukocytoclastic vasculitis. It initially had been considered a variant of Henoch-Schönlein purpura (HSP) but is now classified as a separate entity.1-3 Only approximately 300 to 500 cases of AHEI have been reported worldwide.3,4

    AHEI presents most often in patients between 4 months and 2 years of age, with most cases preceded by a viral infection, an immunization, or antibiotic use.2-4 Classic symptoms include a rapid onset of a rash (petechiae, ecchymoses, and annular, nummular or targetoid purpuric lesions) that involves the face, the ears, and/or the extremities with associated edema.2-5 Patients with AHEI are nontoxic, with or without fever, and, unlike with HSP, rarely have extracutaneous involvement.3,4

    Laboratory test results typically are normal but can include mild leukocytosis, thrombocytosis, elevated CRP and ESR levels, and slightly elevated liver enzyme levels.3,5 Symptoms self-resolve within 1 to 3 weeks.4 Histologic findings of a skin biopsy, if performed, will show small-vessel leukocytoclastic vasculitis.3-5

    AHEI is usually a clinical diagnosis. Among the differential diagnoses are erythema multiforme, drug reaction, Kawasaki disease, meningococcemia, and nonaccidental trauma.2 Treatment is supportive with ibuprofen and acetaminophen.

    OUTCOME OF THE CASE

    At a follow-up visit to the hematology clinic 1 month after his hospital discharge, the infant’s symptoms had resolved.

    Yih Ying (Eva) Yuan, MD, is a pediatric emergency medicine fellow at UT Southwestern Medical Center/Children’s Medical Center Dallas in Dallas, Texas. She is a fellow of the American Academy of Pediatrics.

    Jo-Ann Nesiama, MD, MS, is a pediatric emergency medicine attending physician at UT Southwestern Medical Center/Children’s Medical Center Dallas in Dallas, Texas.

    Craig Huang, MD, is a pediatric emergency medicine attending physician at UT Southwestern Medical Center/Children’s Medical Center Dallas in Dallas, Texas.

    REFERENCES:

    1. Dedeoglu F, Kim S. IgA vasculitis (Henoch-Schönlein purpura): clinical manifestations and diagnosis. UpToDate. https://www.uptodate.com/contents/iga-vasculitis-henoch-schonlein-purpura-clinical-manifestations-and-diagnosis. Updated November 29, 2017. Accessed April 3, 2018.
    2. Javidi Z, Maleki M, Mashayekhi V, Tayebi-Maybodi N, Nahidi Y. Acute hemorrhagic edema of infancy. Arch Iran Med. 2008;11(1):103-106.
    3. Serra e Moura Garcia C, Sokolova A, Torre ML, Amaro C. Acute hemorrhagic edema of infancy. Eur Ann Allergy Clin Immunol. 2016;48(1):22-26.
    4. Chesser H, Chambliss JM, Zwemer E. Acute hemorrhagic edema of infancy after coronavirus infection with recurrent rash. Case Rep Pediatr. 2017;2017:5637503. doi:10.1155/2017/5637503
    5. Anderson J, Wilson P, Leinweber S, Chilton K, Lohr J. A 9-month-old with a purpuric rash and peripheral edema. Consultant Pediatricians. 2015;14(11):490-492.